Research Supported by
the UK Multiple Sclerosis Tissue Bank
|
No. |
Year |
Title of research project |
|
1 |
1998 |
Post
mortem MRI - neuropathology correlative study |
|
2 |
1998 |
(1)
Oligodendrocyte progenitors. (2) The efficiency of remyelination in multiple
sclerosis |
|
3 |
1998 |
Oxidative
DNA damage in the spinal cord in multiple sclerosis |
|
4 |
1998 |
NF-kappaB transcription factor activation in
microglia and macrophages by mediators of inflammation |
|
5 |
1998 |
Expression
of immune molecules by glial cells in health and multiple sclerosis |
|
6 |
1998 |
Human
herpes virus 6 (HHV6) in multiple sclerosis |
|
7 |
1998 |
Study of
oligodendrocytes and myelin in normal appearing white matter (NAWM) and
multiple sclerosis lesions |
|
8 |
1999 |
Extracellular
matrix remodelling and reactive astrocytosis in multiple sclerosis |
|
9 |
1999 |
T cell
reactivity of myelin-oligodendrocyte glycoprotein (MOG) |
|
10 |
1999 |
Nitrosylated
proteins in the central nervous system of subjects with inflammatory disease |
|
11 |
1999 |
(i) The
role of chemokines and their receptors in the pathogenesis of multiple
sclerosis; and, (ii) The role of urokinase, its receptors and ADAMS in the
pathogenesis of multiple sclerosis |
|
12 |
1999 |
(1)
Schwann cell repair in multiple sclerosis lesions of the brain and spinal
cord. (2) Oligodendrocyte progenitors in multiple sclerosis lesions |
|
13 |
1999 |
Intercellular
lipid signalling and control of oligodendrocyte myelination |
|
14 |
1999 |
Sodium channels
in multiple sclerosis |
|
15 |
1999 |
Distribution
of lactoferrin in multiple sclerosis lesions |
|
16 |
2000 |
Development
of an in vitro model for the human blood-brain barrier |
|
17 |
2000 |
Expression
of glial signalling molecules in adult optic nerve |
|
18 |
2000 |
Purification
of human myelin-oligodendrocyte glycoprotein (MOG) from normal and multiple
sclerosis central nervous system tissue |
|
19 |
2000 |
The
mechanism of oligodendrocyte development and myelination in the normal and
pathologic central nervous system |
|
20 |
2000 |
Characterisation
of stress proteins and microtubule associated proteins in human brain tissue
of control and multiple sclerosis patients |
|
22 |
2000 |
Influence
of axonal signals on myelination in the central nervous system |
|
23 |
2000 |
The role
of chemokines and their receptors in the migration response of adult human
microglia |
|
24 |
2000 |
Corpora
amylacea in multiple sclerosis |
|
25 |
2000 |
Expression
analysis of Laminin-related gene – 1 |
|
26 |
2000 |
Analysis
of the T-cell receptor repertoire in the central nervous system of multiple
sclerosis patients |
|
27 |
2000 |
Detection
of PSA - NCAM precursors in multiple sclerosis lesions |
|
28 |
2000 |
Neurotransmitter
receptors on astrocytes in multiple sclerosis |
|
29 |
2001 |
Neuronal
number and size changes in the grey matter of multiple sclerosis patients |
|
30 |
2002 |
Oxidative
DNA damage in the spinal cord in multiple sclerosis |
|
31 |
2002 |
The role
of chemokines and their receptors in the pathogenesis of multiple sclerosis |
|
32 |
2002 |
Determination
of human herpes virus -6, -7 and -8 (HHV-6, HHV-7 and HHV-8) DNA and gene
expression in multiple sclerosis |
|
33 |
2002 |
Molecular
and cellular basis of blood-brain barrier injury in multiple sclerosis |
|
34 |
2002 |
Epitope
mapping of myelin antigens |
|
35 |
2002 |
Dendritic
cells in central nervous system autoimmunity: Role in maintaining the
autoimmune response and potential new target for immunotherapy |
|
36 |
2002 |
An
investigation into the role of ADAM 17 in the pathogenesis of multiple
sclerosis |
|
37 |
2002 |
Axonal
loss in multiple sclerosis: Role of mitochondria and ion channels |
|
38 |
2003 |
Gene
therapy by expression of complement regulators in experimental models of
demyelination |
|
39 |
2003 |
Expression
profiling of the Parkinsonian brain using microarray analysis |
|
40 |
2003 |
Molecular
and cell biology of Cadherin-10 |
|
41 |
2003 |
Oligodendrocyte
progenitor cell transcription factors in multiple sclerosis lesions |
|
42 |
2003 |
Expression
of MHC class I chain-related gene A (MICA) in multiple sclerosis plaques |
|
43 |
2003 |
Proteomic
analysis in multiple sclerosis brains and controls |
|
44 |
2003 |
(i)
Study of nodal and perinodal axonal proteins in demyelinated and partially
remyelinated multiple sclerosis lesions; and, (ii) Analysis of secreted and
surface guidance molecules expressed in multiple sclerosis lesions |
|
45 |
2003 |
Is there
evidence that human oligodendrocyte progenitors express myelin-oligodendrocyte
glycoprotein (MOG)? |
|
46 |
2003 |
Understanding
the cellular and molecular mechanisms of glial cell injury and repair in
multiple sclerosis |
|
47 |
2003 |
Functional
analysis of Siglecs in pathological progression of multiple sclerosis |
|
48 |
2003 |
Does
Interleukin-1α genotype affect the pathological phenotype of MS? |
|
49 |
2003 |
Do
chemokines contribute to blood-brain barrier dysfunction in multiple
sclerosis? An in vitro study on
astrocytes and brain endothelial cells |
|
50 |
2003 |
Characterization
of key factors orchestrating B cells expansion and lymphoid neogenesis in the
central nervous system of multiple sclerosis patients |
|
51 |
2003 |
Analysing
cholinergic neurons and fibres in multiple sclerosis |
|
52 |
2003 |
A pilot
study of brain iron deposition in multiple sclerosis using magnetrometry and
magnetic extraction techniques |
|
53 |
2003 |
Measuring
cortical thickness in multiple sclerosis |
|
54 |
2003 |
Identification
of proteins present in multiple sclerosis lesions |
|
55 |
2003 |
An
evaluation of the expression of cannabinoid receptors in the central nervous
system of patients with multiple sclerosis and controls |
|
56 |
2003 |
Profiling
and localization of matrix metalloproteinases and metalloproteinase
inhibitors in the central nervous system of multiple sclerosis patients |
|
57 |
2004 |
Antigen
presenting cell – T-cell interactions in the central nervous system : the
role of antigen-presentation, costimulation and non-classical MHC molecules
in neuroinflammation |
|
58 |
2004 |
Integrin-extracellular
matrix expression in multiple sclerosis lesions |
|
59 |
2004 |
Mechanism
of axon damage and loss in multiple sclerosis: a neuropathological study |
|
60 |
2004 |
Differential
expression of myelin antigens in the central nervous system and their impact
on the clinical course of experimental demyelinating disease and lesion
location |
|
61 |
2004 |
Role of
axonal damage and autoimmunity to axonal components in the pathogenesis of
experimental demyelinating diseases |
|
62 |
2004 |
Pathogenic
and predictive significance of autoimmunity to myelin oligodendrocyte
glycoprotein in experimental demyelinating disease and multiple sclerosis |
|
63 |
2004 |
Molecular
and functional analysis of the B/Plasma-cell repertoire in human brain tissue
plaques of multiple sclerosis patients |
|
64 |
2004 |
Matrix
metalloproteinases, the perineuronal net and nerve cell damage in multiple
sclerosis |
|
65 |
2004 |
Expression
of alpha synuclein in central myelin in patients with Parkinson's disease |
|
66 |
2004 |
IFN-beta
induced adenosine production on the endothelium: a mechanism mediated by CD73
(ecto-5'-nucleotidase) up- regulation |
|
67 |
2004 |
Migration
and persistence of B cells/plasma cells in the central nervous system of multiple
sclerosis patients |
|
68 |
2004 |
Spinal
cord pathology in Idiopathic Parkinson's Disease |
|
69 |
2004 |
Brain-Net
Project – Optimisation of an RNA extraction procedures for future studies on
gene expression in neurological diseases |
|
70 |
2004 |
Analysis
of T cell derived cytokines |
|
71 |
2004 |
A
pathological study of normal-appearing white matter in autopsy multiple
sclerosis brain |
|
72 |
2004 |
Further
studies on the molecular and cellular basis of blood-brain barrier injury in
multiple sclerosis: (i) the grey matter and (ii) primary progressive MS |
|
73 |
2004 |
Phenotype
determination of human brain endothelium by transcription factors |
|
74 |
2004 |
Toll-like
receptors as a repair switch on human glial cells |
|
75 |
2004 |
Assessment
of multiple sclerosis pathology using magnetic resonance and quantitative
histology |
|
76 |
2004 |
A
comparison of brain specific proteins and histopathology in post mortem
multiple sclerosis brain |
|
77 |
2004 |
Changes
in the endocannabinoid system in multiple sclerosis |
|
78 |
2004 |
The role
of the kelch repeat protein Mayven in process formation in oligodendrocytes |
|
79 |
2005 |
Investigation
into the potential pathogenic role of ds-DNA antibodies in multiple sclerosis |
|
80 |
2005 |
To
investigate the extent and nature of Schwann cell remyelination in multiple
sclerosis |
|
81 |
2005 |
Assessment
of olfactory bulb pathology and correlation with disease severity in
Parkinson's Disease |
|
82 |
2005 |
Investigations
regarding presence of JC virus in central nervous system of patients with
multiple sclerosis and controls |
|
83 |
2005 |
Potential
influence of integrin alpha4-dependent processes in the contribution of
efficacy/safety profile of Tysabri/natalizumab |
|
84 |
2005 |
Topographic
analysis of the distribution of lesions in multiple sclerosis |